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Common adverse drug reactions associated with the cephalosporin
therapy includes diarrhea, nausea, rash, electrolyte disturbances.
It even leads to pain and inflammation at injection site. Infrequent
includes vomiting, headache and dizziness, oral and vaginal
candidacies. Other major adverse effects include pseudomembranous
colitis, super infection and eosinophilia with high fever. The
cross-reactivity rate with Cefsulodin - Cefzil is much lower, having
no significantly increased risk of reactivity in the studies
examined.
A figure of 10% of patients with allergic hypersensitivity to
penicillin or cefsulodin also show less sensitivity of sense of
touch, anemia, arthralgia that is relating the pains in the joints.
Originated from a study 1975 showed that Cefsulodin - Cefzil is not
a safety option for women who are pregnant during the period can
lead to deficiencies. "Safety first" policy is useful and assumed to
applicable to all members consuming such drugs. Hence, it causes
severe defects in patients with a history of severe, immediate
allergic reactions.
Severe disease in the later stages includes urticaria, anaphylaxis,
interstitial nephritis, etc to drugs like cefsulodin, penicillin.
This however reviews in the light of recent epidemiological work
suggesting that for many second (or later) generation cefsulodin is
less harmless. Cefsulodin are associated with hypoprothrombinemia
and disulfiram-like reactions. These include latamoxef, cefmenoxime,
moxalactam and cefotetan. This is due to the N-methylthiotetrazole (NMTT)
side chain of these cefsulodin, which blocks the enzyme vitamin K
epoxide reductase. Any drug having side effects does not mean that
all may suffer it.
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